




The Zebra ZD621 brings fast print speeds, excellent quality, simple management and security to a compact 4-inch desktop printer. Its innovative architecture supports more simultaneous operations and gives Zebra room to extend capabilities as software, networks and business requirements evolve.
Choose direct thermal, thermal transfer or a dedicated ZeroLiner linerless configuration. The broader ZD621 family also includes healthcare and RFID models; their specialized materials, power supplies and RFID encoding capabilities apply only to the corresponding configurations.
The ZD621 is engineered to perform more operations simultaneously and keep pace with emerging applications. An optional 802.11ax and Bluetooth 5.3 radio supports Wi-Fi 6/6E, WPA3 security, fast data rates and improved roaming; Wi-Fi 5 with Bluetooth 4.2 remains another available dual-radio choice.
A dedicated ZD621 linerless configuration works with Zebra ZeroLiner labels, eliminating backing liners and the peeling step. Zebra states that ZeroLiner provides up to 50% more labels per roll, reducing roll changes, material use, waste and related CO2 emissions.
At 203 dpi, the ZD621 prints up to 8 inches per second; optional 300 dpi provides finer detail at up to 6 inches per second.
The ZD621 platform spans direct thermal, thermal transfer, linerless, healthcare and RFID models, with capabilities varying by configuration. Its 4-inch format serves retail, hospitality, healthcare and government workflows including shelf, pharmacy and food-safety labels, receipts, tickets, wristbands, specimen labels and document tracking.
Zebra DNA setup tools, wizards and printer emulations simplify deployment. Five LED status icons and three control buttons communicate printer state with minimal training, while built-in security and remote-management capabilities help reduce IT effort and harden the printing environment.
OpenACCESS, color-coded touch points and an updated media path guide operators through quick supply changes. Thermal transfer users can replace 74-meter or 300-meter ribbon with less mess and training than an unguided mechanism.
Thermal transfer models use a media dancer to maintain quality across speeds and accept either 74-meter or 300-meter ribbon rolls.
Full-width movable reflective and multi-position gap sensors support roll-fed or fan-fold media, die-cut or continuous stock, black marks, tags, receipts and wristbands. Factory- or field-installable dispenser/peeler and cutter modules let the printer adapt without replacement.
Select configurations add a 4.3-inch full-color touch display with guided menus, calibration assistance and troubleshooting animations. The display supports stand-alone applications and is tested for temperature, humidity, dust and other environmental challenges consistent with Zebra's printer portfolio.
ZPL and EPL support allows established label formats and applications to continue in service. Zebra DNA Printer Emulations can also interpret selected languages associated with other brands, easing mixed-fleet replacements.
Ethernet, RS-232 serial, USB 2.0 and USB Host are standard. Optional Wi-Fi 6/Bluetooth 5.3 or Wi-Fi 5/Bluetooth 4.2 radios, BLE setup through Zebra's Printer Setup Utility and the Print Touch NFC tag support networked, mobile and tap-to-pair workflows.
The optional 2750 mAh battery powers the printer for a full shift at maximum print speed and supports all media-handling options. A ZD621 carrying case with shoulder strap and handles can bring the printer and battery to the point of work, but it does not fit when a cutter or peeler is installed.
Movable reflective and multi-position transmissive sensors accommodate varied marks, gaps and media layouts. The 5-inch maximum roll diameter and optional core adapters broaden supply choices without changing the basic desktop footprint.
Zebra DNA, powered by Link-OS, provides an integrated environment for setup, interoperability and dependable printing.
Printer Profile Manager Enterprise lets administrators discover, configure, secure and troubleshoot networked printers remotely through a browser-based interface.
PrintSecure helps create secure connections, assess vulnerabilities and block unauthorized access. Security policies and printer configurations can evolve after deployment instead of remaining fixed at installation.
Zebra DNA remote-management, analytics and security capabilities help an MPS provider optimize printer fleets, automate supply replenishment and maintain security without visiting every device. The same tools help internal IT teams monitor and update distributed printers.
Zebra designs and pretests labels, tags, receipt paper, linerless media and ribbons for consistent printer performance.
Zebra OneCare plans add defined service levels and coverage beyond the standard warranty through Zebra and its network of more than 10,000 partners.
The standard package includes the ZD621 printer, AC power supply and power cord, USB cable, Quick Start Guide and Regulatory Guide. Thermal transfer configurations also include 1-inch and 0.5-inch take-up cores plus two adapters for 300-meter non-Zebra ribbon cores.
Touch display, wireless, battery, linerless, healthcare, RFID and media-handling capabilities depend on the selected configuration. A media-locking cabinet and enclosed power-supply accessory are limited to specific ZD621 configurations and are not represented as standard equipment.

POSGuys offers labels and ribbons sized for ZD621 direct thermal and thermal transfer applications. Having trouble finding the right media? Give our Label Selector Tool a try or contact us for help matching media width, roll and core size, sensing method, ribbon, and printer configuration.
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 203 dpi, USB, Ethernet, Serial
DPI:
203
User Interface.:
Color Touch LCD
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; Color Touch LCD, 300 dpi, USB, Ethernet, Serial
DPI:
300
User Interface.:
Color Touch LCD
Print Method:
Direct Thermal
Add Ons:
Tear
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 203 dpi, USB, Ethernet, Serial, WiFi, BT4
DPI:
203
User Interface.:
Color Touch LCD
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 300 dpi, USB, Ethernet, Serial
DPI:
300
User Interface.:
Color Touch LCD
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 300 dpi, USB, Ethernet, Serial, WiFi, BT4
DPI:
300
User Interface.:
Color Touch LCD
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Direct Thermal Barcode Printer; 203 dpi, USB, Ethernet, Serial, Tearbar
DPI:
203
User Interface.:
5 status icon, 3 button UI
Print Method:
Direct Thermal
Add Ons:
Tear
Interface:
USB, Ethernet, Serial
Thermal Transfer Printer (74/300M) ZD621; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
Direct Thermal Printer ZD621; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
Thermal Transfer Printer (74/300M) ZD621; 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
Direct Thermal Printer ZD621; Color Touch LCD, 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
Direct Thermal Printer ZD621; Color Touch LCD, 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.2, USA/Canada, US Cord, Swiss Font, EZPL
Direct Thermal Printer ZD621; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, Cutter, US Cord, Swiss Font, EZPL
Direct Thermal Printer ZD621; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL,TAA
Thermal Transfer Printer (74/300M) ZD621R, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, USA/Canada, RFID - UHF, US Cord, Swiss Font, EZPL,TAA
Thermal Transfer Printer (74/300M) ZD621; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL,TAA
Thermal Transfer Printer (74/300M) ZD621; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL,TAA
Direct Thermal Printer ZD621; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL,TAA
Disco Direct Thermal Printer ZD621, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ac, BT4, USA/Canada, Linerless with Cutter and Label Taken Sensor, US Cord, Swiss Font, EZPL
Thermal Transfer Printer (74/300M) ZD621; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ac, BT4, USA/Canada, US Cord, Swiss Font, EZPL
Direct Thermal Printer ZD621; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, Linerless with Label Taken Sensor, US Cord, Swiss Font, EZPL
Thermal Transfer Printer (74/300M) ZD621; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, Cutter, US Cord, Swiss Font, EZPL
Direct Thermal Printer ZD621; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL.
Direct Thermal Printer ZD621; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, Dispenser (Peeler), US Cord, Swiss Font, EZPL
Direct Thermal Printer ZD621; Color Touch LCD, 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, Linerless with Cutter and Label Taken Sensor, US Cord, Swiss Font, EZPL
ZD621 Direct Thermal Barcode Printer; 203 dpi, USB, Ethernet, Serial, Cutter
DPI:
203
User Interface.:
5 status icon, 3 button UI
Add Ons:
Cutter
Print Method:
Direct Thermal
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; 300 dpi, USB, Ethernet, Serial, WiFi, BT4
DPI:
300
User Interface.:
5 status icon, 3 button UI
Print Method:
Direct Thermal
Add Ons:
Tear
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer, Healthcare, Color Touch LCD; 300 dpi, USB, Ethernet, Serial
DPI:
300
User Interface.:
Color Touch LCD
Extra Features:
Healthcare
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; 203 dpi, USB, Ethernet, Serial, Linerless with Cutter and Label Taken Sensor
DPI:
203
User Interface.:
5 status icon, 3 button UI
Add Ons:
Cutter
Print Method:
Direct Thermal
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; Healthcare, Color Touch LCD; 300 dpi, USB, Ethernet, Serial
DPI:
300
User Interface.:
Color Touch LCD
Print Method:
Direct Thermal
Extra Features:
Healthcare
Add Ons:
Tear
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer, Healthcare, Color Touch LCD; 203 dpi, USB, Ethernet, Serial, WiFi, BT4
DPI:
203
User Interface.:
Color Touch LCD
Extra Features:
Healthcare
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Direct Thermal Barcode Printer; Healthcare, Locking, Color Touch LCD; 203 dpi, USB, Ethernet, Serial
DPI:
203
User Interface.:
Color Touch LCD
Print Method:
Direct Thermal
Extra Features:
Healthcare
Add Ons:
Tear
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet, Serial
DPI:
203
User Interface.:
5 status icon, 3 button UI
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet, Serial, Dispenser (Peeler)
DPI:
203
User Interface.:
5 status icon, 3 button UI
Add Ons:
Dispenser (Peeler)
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet, Serial, Cutter
DPI:
203
User Interface.:
5 status icon, 3 button UI
Add Ons:
Cutter
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; Color Touch LCD, 203 dpi, USB, Ethernet, Serial, WiFi, BT4
DPI:
203
User Interface.:
Color Touch LCD
Print Method:
Direct Thermal
Add Ons:
Tear
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Direct Thermal Barcode Printer; 203 dpi, USB, Ethernet, Serial, Dispenser (Peeler)
DPI:
203
User Interface.:
5 status icon, 3 button UI
Print Method:
Direct Thermal
Add Ons:
Dispenser (Peeler)
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 203 dpi, USB, Ethernet, Serial, WiFi, BT4, Dispenser (Peeler)
DPI:
203
User Interface.:
Color Touch LCD
Add Ons:
Dispenser (Peeler)
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 203 dpi, USB, Ethernet, Serial, WiFi, BT4, Cutter
DPI:
203
User Interface.:
Color Touch LCD
Add Ons:
Cutter
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 300 dpi, USB, Ethernet, Serial, WiFi, BT4, Dispenser (Peeler)
DPI:
300
User Interface.:
Color Touch LCD
Add Ons:
Dispenser (Peeler)
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 300 dpi, USB, Ethernet, Serial, WiFi, BT4, Cutter
DPI:
300
User Interface.:
Color Touch LCD
Add Ons:
Cutter
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer, Color Touch LCD; 203 dpi, USB, Ethernet, Serial, Cutter
DPI:
203
User Interface.:
Color Touch LCD
Add Ons:
Cutter
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet, Serial, WiFi, BT4, Dispenser (Peeler)
DPI:
203
User Interface.:
5 status icon, 3 button UI
Add Ons:
Dispenser (Peeler)
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet, Serial, WiFi, BT4, Cutter
DPI:
203
User Interface.:
5 status icon, 3 button UI
Add Ons:
Cutter
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer; 300 dpi, USB, Ethernet, Serial
DPI:
300
User Interface.:
5 status icon, 3 button UI
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Thermal Transfer Barcode Printer; 300 dpi, USB, Ethernet, Serial, WiFi, BT4
DPI:
300
User Interface.:
5 status icon, 3 button UI
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer; 300 dpi, USB, Ethernet, Serial, Dispenser (Peeler)
DPI:
300
User Interface.:
5 status icon, 3 button UI
Add Ons:
Dispenser (Peeler)
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; Color Touch LCD, 203 dpi, USB, Ethernet, Serial
DPI:
203
User Interface.:
Color Touch LCD
Print Method:
Direct Thermal
Add Ons:
Tear
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; Color Touch LCD, 203 dpi, USB, Ethernet, Serial, 802.11ac, BT4, Dispenser (Peeler)
DPI:
203
User Interface.:
Color Touch LCD
Print Method:
Direct Thermal
Add Ons:
Dispenser (Peeler)
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Direct Thermal Barcode Printer; Color Touch LCD, 203 dpi, USB, Ethernet, Serial, WiFi, BT4, Linerless with Cutter and Label Taken Sensor
DPI:
203
User Interface.:
Color Touch LCD
Add Ons:
Cutter
Print Method:
Direct Thermal
Interface:
USB, Ethernet, Serial, WiFi 802.11ac, BT4
ZD621 Thermal Transfer Barcode Printer, Healthcare, Color Touch LCD; 203 dpi, USB, Ethernet, Serial
DPI:
203
User Interface.:
Color Touch LCD
Extra Features:
Healthcare
Add Ons:
Tear
Print Method:
Thermal Transfer
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; Healthcare, Color Touch LCD; 203 dpi, USB, Ethernet, Serial
DPI:
203
User Interface.:
Color Touch LCD
Print Method:
Direct Thermal
Extra Features:
Healthcare
Add Ons:
Tear
Interface:
USB, Ethernet, Serial
ZD621 Direct Thermal Barcode Printer; Healthcare, Locking, Color Touch LCD; 203 dpi, USB, Ethernet, Serial, Cutter
DPI:
203
User Interface.:
Color Touch LCD
Add Ons:
Cutter
Print Method:
Direct Thermal
Extra Features:
Healthcare
Interface:
USB, Ethernet, Serial
Single Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core. Single Roll. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).
Kit, Printhead 300 dpi, ZD621D
Kit, Printhead 300 dpi, ZD621T, ZD621R
Kit, Printhead 203 dpi, ZD621D
Kit, Printhead 203 dpi, ZD621T, ZD621R
Kit, Upgrade, Cutter, ZD621T, ZD621R
Upgrade, Cutter, ZD421D, ZD621D - Direct Thermal Models Only
Zebra OneCare, Essential, Purchased within 30 days of Device, ZD621d, ZD621t, ZD621-RFID, 5 Years, Comprehensive
Kit, Upgrade, Dispenser, ZD421D, ZD621D
OneCare, Essential, Purchased within 30 days of Device, ZD621d, ZD621t, ZD621-RFID, 3 Years, Comprehensive
Replacement Power Supply for Zebra Desktop Printer. 75W/24V with US & EU AC cords. Compatible with: ZD410, ZD411, ZD420, ZD421, ZD620, ZD621, ZD500.
Zebra Zebra OneCare Essential Purchased within 30 days of Device ZD6x0 3 Years Comprehensive
4" Ribbon Take-Up Core For 4" Thermal Transfer Printers. 0.5" OD. (Three Pack)
Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core, 6 Rolls. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).
Wireless Module, WiFi 802.11ac, MFI 3.0, Bluetooth 4.1, USA & Canada, ZD421, ZD621, ZD411
Media Core Adaptors for 1.5", 2.0", 3.0" diameter cores. Set of 1 each. Compatible with Zebra ZD421 & ZD621 Printers.
Attached Power Supply for use with Printer Power Carts. This removes the need for an external Power Supply. Attached Power Supply sits below the printer and is compatible with the Zebra ZD421 and ZD621. Must Purchase AC Power Cable (29928 or 29926) Separately.
Universal AC Power Cord. 8ft (2.4m). 125.0 V / 13 A.
Universal AC Power Cord. 4ft (1.6m). 125.0 V / 13 A.
Peeler (Dispenser) Upgrade Module for Zebra ZD621T, ZD621R, and ZD421C Printers. NOT backwards compatible with the ZD420 or ZD620
Battery for Zebra Desktop Printers. Compatible with ZD411, ZD421, ZD621, ZD410, ZD420, and ZD620. Requires Base Housing (P1080383-602 for ZD411/ZD611 / P1080383-600 for ZD421 & ZD621).
Base Housing for Zebra Printer Battery. Compatible with Zebra ZD421, ZD621, ZD420, and ZD620. Purchase Battery (P1080383-603) Separately.