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Zebra ZD621 Healthcare
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Zebra ZD621 Healthcare

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Premium desktop printing built for healthcare environments.

The 4-inch Zebra ZD621 Healthcare is designed for clinical labeling with direct-thermal and thermal-transfer configurations, 203 or 300 dpi output and a standard 4.3-inch full-color touch display. It supports specimen, prescription, laboratory, patient-record, wristband and asset workflows.

Disinfectant-ready UV-resistant plastics, a sealed-button interface and an IEC 60601-1 compliant power supply suit regular healthcare cleaning. Zebra DNA for Printers and Link-OS add setup, security and remote-management tools for long-term deployment.

Zebra ZD621 Healthcare desktop printer overview.

Key Specifications

  • Print method: Direct thermal or thermal transfer, depending on configuration
  • Resolution: 203 dpi; optional 300 dpi
  • Maximum print width: 4.09 in. at 203 dpi; 4.27 in. at 300 dpi
  • Print speed: Up to 8 ips at 203 dpi; up to 6 ips at 300 dpi
  • Media and ribbon handling: Roll or fan-fold labels, tags, receipts and wristbands; 74 m or 300 m ribbon on thermal-transfer models
  • Connectivity: Ethernet, serial, USB 2.0 and USB Host; optional Wi-Fi 6/5 with Bluetooth
  • Duty / application fit: Healthcare desktop labeling for specimens, prescriptions, labs, wristbands, assets and records
  • Dimensions and weight: DT: 8.7 x 7.0 x 5.9 in., 3.6 lb.; TT: 10.5 x 8.0 x 7.5 in., 5.5 lb.
  • Warranty: Minimum 2 years; varies by region

In the Box

  • Zebra ZD621 Healthcare printer
  • IEC 60601-1 compliant power supply
  • Region-appropriate power cord
  • USB cable
  • Quick Start Guide
  • Regulatory Guide

Package note: Thermal-transfer configurations also include ribbon take-up cores and two 300 m non-Zebra ribbon-core adapters. Other accessories are sold separately unless the selected option explicitly includes them.

Designed for Healthcare

Cleanable and Safely Powered

Disinfectant-ready UV-resistant plastics and a sealed-button interface support routine cleaning, while the healthcare power supply meets IEC 60601-1.

Secure Clinical Printing

Zebra PrintSecure and Zebra DNA tools help create secure connections, identify vulnerabilities and manage printers without exposing sensitive workflows.

Premium Desktop Performance

Fast, Detailed Output

Choose 203 dpi for up to 8 ips throughput or 300 dpi for smaller text, dense barcodes and compact healthcare media at up to 6 ips.

Flexible Media Handling

Movable reflective and transmissive sensors support labels, tags, receipt stock and wristbands; cutter and dispenser/peeler options can be added for specialized workflows.

Easy to Use and Manage

Guided Touch Interface

The standard 4.3-inch touch display provides setup wizards, media-loading guidance, troubleshooting animations and visible status icons.

Connected for Growth

Standard wired interfaces and optional Wi-Fi 6 or Wi-Fi 5 dual radios support deployment flexibility, while Link-OS and remote tools simplify fleet management.

Adapt to the Point of Care

Portable Power Option

An optional battery can support a full shift at maximum print speed, allowing compatible carts or carrying cases to bring printing closer to the application.

Built for Long Service

A more capable architecture, field-installable connectivity and media-handling options help the ZD621 Healthcare adapt as workflows change.

Zebra-compatible barcode labels and ribbon

Looking for Compatible Labels or Ribbon?

Match the selected print method, media width, roll and core size, sensing method and ribbon to the job. Use the POSGuys Label Selector Tool or contact us for help selecting supplies for a ZD621 Healthcare configuration.

Find LabelsView Ribbon
Dimensions
  • Direct Thermal: 8.7" L x 7.0" W x 5.9" H
  • Thermal Transfer: 10.5" L x 8.0" W x 7.5" H
Weight
  • Direct Thermal: 3.6 lbs.
  • Thermal Transfer: 5.5 lbs.
Print Method
  • Direct Thermal
  • Thermal Transfer
Resolution
  • 203 dpi
  • 300 dpi optional
Print Width
  • 203 dpi: up to 4.09"
  • 300 dpi: up to 4.27"
Print Speed
  • 203 dpi: up to 8" per second
  • 300 dpi: up to 6" per second
Media Width
  • Direct Thermal: 0.585" to 4.25"
  • Thermal Transfer: 0.585" to 4.65"
Label Length
  • Minimum: 0.25"
  • Maximum: 39.0"
Media Roll Size
  • Maximum OD: 5.0"
  • Core ID: 0.5" and 1.0" standard
  • Optional adapters: 1.5", 2.0", and 3.0"
Media Thickness
0.003 in. (0.08 mm) min.; 0.0075 in. (0.19 mm) max. (tear-off mode only)
Media Types
Roll-fed or fan-fold, die cut or continuous with or without black mark, label or tag stock, continuous receipt paper, wristbands
Ribbon Outside Diameter
2.6 in./66 mm (300 m); 1.34 in./34 mm (74 m)
Ribbon Standard Length
984 ft. (300 m); 243 ft. (74 m)
Ribbon Ratio
  • 1:4 ribbon to media (300 m)
  • 1:1 ribbon to media (74 m)
Ribbon Width
1.33 in./33.8 mm — 4.3 in./109.2 mm
Ribbon Core I.D.
  • 300 meter ribbon 1 in./25.4 mm
  • 74 meter ribbon 0.5 in./12.7 mm
Operating Temperature
40° to 105° F/4.4° to 41° C
Operating Humidity
10% to 90% non-condensing
Storage Humidity
5% to 95% non-condensing
Electrical
Auto-detectable (PFC Compliant) 100-240VAC, 50-60Hz; ENERGY STAR certified; Energy Efficiency Level VI certified; optional 2750 mAh battery; Healthcare models include IEC60601-1 certified power supply
Media Handling
Dispenser/Peeler: label peel and present with label present sensor (factory installed or field installable) Cutter (factory installed or field installable)
Communications
Factory installed: Wi-Fi 6 (802.11ax) and Bluetooth 5.3 (MIMO); field installable: Wi-Fi 6 (802.11ax) and Bluetooth 5.3 (SISO); factory or field installable: Wi-Fi 5 (802.11ac) and Bluetooth 4.2
Battery
Provides power to the printer to support a full shift of printing at maximum print speed; supports all connectivity and media handling options
Carrying Case
Carrying case with shoulder strap and handles makes it easy to bring your desktop printer and battery to the point of application
Keyboard Display Unit
Zebra Keyboard Display Unit (ZKDU) for stand-alone printing solutions
Media Locking Cabinet
Mechanical lock with 2 keys; Kensington™ lock slot; available on ZD621 healthcare direct thermal model only
Enclosed Power Supply
Attached power supply accessory for cord-free installation
Barcode Ratios
2:1 and 3:1
1D Barcodes
Code 11, Code 39, Code 93, Code 128, ISBT-128, UPC-A, UPC-E, EAN-8, EAN-13, UPC and EAN 2-or 5-digit extensions, Plessey, Postnet, Standard 2-of- 5, Industrial 2-of-5, Interleaved 2-of-5, Logmars, MSI, Codabar and Planet Code
2D Barcodes
Codablock, PDF417, Code 49, DataMatrix, MaxiCode, QR Code, MicroPDF, Aztec
Fonts and Graphics
16 resident expandable ZPL II bitmap fonts, two resident scalable ZPL fonts, five resident expandable EPL2 fonts, native open-type font support, Unicode compliant. China units include SimSun simplified Chinese font
Printer Supplies
For industry-leading quality, service and thermal printing expertise, choose Zebra Certified Supplies to ensure consistent, optimized performance for your Zebra printer.
Environment
• RoHS Directive 2011/65/EU; Amendment 2015/863
A complete list of product and materials compliance, please visit www.zebra.com/environment
Included in the Box
Printer, empty ribbon take-up cores (1 in. and 0.5 in.)*, 300 m ribbon core adapters for non-Zebra ribbon (2)*, AC power supply, power cord(s), USB cable, Quick Start Guide, Regulatory Guide
* Empty ribbon take-up cores and ribbon core adapters included with ZD621 thermal transfer models only
Product Warranty
ZD600 Series printers are warranted against defects in workmanship and materials for a minimum period of 2 (two) years from the date of shipment. Warranty varies by region. For complete warranty details, please visit www.zebra.com/warranty
Print Spooler Reset (Used To Clear Stuck Print Queues)
Download
Windows Driver (Version 10)
Download
Zebra Setup Utility
Download
Zebra ZD621 Healthcare Accessory Guide
Download
Zebra ZD621 Healthcare Spec Sheet
Download

Shop ZD621 Healthcare Models

ZD6AL42-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Locking, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$979.07

ZD6AH42-D01R01EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.2, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial, 802.11ax, BT5.2

$1068.86

ZD6AH42-301F00EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial

$979.07

ZD6AH42-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL.

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$890.15

ZD6AH43-301F00EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

300

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial

$1068.00

ZD6AH43-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$979.07

ZD6AL42-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Locking, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$979.07

ZD6AL42-D21F00EZ

Direct Thermal Printer ZD621; Healthcare, Locking, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, Cutter, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Cutter

Print Method:

Direct Thermal

Interface:

USB, USB Host, Ethernet, Serial

$1180.25

ZD6AH43-D01R01EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial, 802.11ax, BT5.3

$1158.32

ZD6AL43-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Locking, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$1068.00

ZD6AH42-301F00EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial

$979.07

ZD6AH42-301L01EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ac Wi-Fi, Bluetooth 4.1, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

203

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac, BT4

$1157.80

ZD6AH42-D01L01EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 203 dpi, USB, USB Host, Ethernet, Serial, 802.11ac Wi-Fi, Bluetooth 4.1, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

203

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac

$1068.87

ZD6AH43-301L01EZ

Thermal Transfer Printer (74/300M) ZD621, Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ac Wi-Fi, Bluetooth 4.1, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

300

Add-Ons:

Tear

Print Method:

Thermal Transfer Printer

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac, BT4

$1246.72

ZD6AH43-D01F00EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, BTLE5, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial

$979.07

ZD6AH43-D01L01EZ

Direct Thermal Printer ZD621; Healthcare, Color Touch LCD; 300 dpi, USB, USB Host, Ethernet, Serial, 802.11ac Wi-Fi, Bluetooth 4.1, USA/Canada, US Cord, Swiss Font, EZPL

DPI:

300

Print Method:

Direct Thermal

Add-Ons:

Tear

Interface:

USB, USB Host, Ethernet, Serial, 802.11ac, BT4

$1157.80

Shop ZD621 Healthcare Accessories

P1080383-603

Battery for Zebra Desktop Printers. Compatible with ZD411, ZD421, ZD621, ZD410, ZD420, and ZD620. Requires Base Housing (P1080383-602 for ZD411/ZD611 / P1080383-600 for ZD421 & ZD621).

$767.50

P1080383-600

Base Housing for Zebra Printer Battery. Compatible with Zebra ZD421, ZD621, ZD420, and ZD620. Purchase Battery (P1080383-603) Separately.

$100.56

P1112640-239A

Kit, Wireless Module, WiFi 802.11ac, MFI 3.0, Bluetooth 4.1, USA & Canada, ZD621T, ZD421C

$234.61

ZKDU-001-00

Keyboard Display Unit (ZKDU), For all EPL and ZPL Printers, 62-Key QW

$414.25

P1112640-232

Kit, Upgrade, Cutter, ZD621T, ZD621R

$268.11

P1112640-233

Peeler (Dispenser) Upgrade Module for Zebra ZD621T, ZD621R, and ZD421C Printers. NOT backwards compatible with the ZD420 or ZD620

$53.62

P1080383-022

Media Core Adaptors for 1.5", 2.0", 3.0" diameter cores. Set of 1 each. Compatible with Zebra ZD421 & ZD621 Printers.

$60.32

P1112640-240

Kit, Printhead 203 dpi, ZD621T, ZD621R

$179.09

P1112640-241

Kit, Printhead 300 dpi, ZD621T, ZD621R

$373.80

P1079903-026

Replacement Power Supply for Zebra Desktop Printer. 75W/24V with US & EU AC cords. Compatible with: ZD410, ZD411, ZD420, ZD421, ZD620, ZD621, ZD500.

$200.83

29928

Universal AC Power Cord. 8ft (2.4m). 125.0 V / 13 A.

$17.51

29926

Universal AC Power Cord. 4ft (1.6m). 125.0 V / 13 A.

$15.12

SG-DM-CASE2-01

KIT, Accessory, Thermal Transfer Soft Carrying Case, ZD42X/ZD62X printer with battery attachment

$426.47

P1112640-238

Kit, Ethernet and Serial Module, ZD621T, ZD621R

$131.04

P1080383-037

ZD420C, Kit, Adapter bracket enables mounting a ZD420C in the same location as an existing GK/GX TT is currently mounted. Allows usage of the GK/GX TT hole pattern to mount a ZD420C

$60.32

BRKT-DPA-SK1-01

PrintKiosk mounting bracket for ZD4/6 printers and CC6000 tablet (75/100mm VESA mounting plate)

$365.36

BRKT-DPA-SK1-02

PrintKiosk mounting bracket for ZD4/6 printers and CC600 tablet (75mm only VESA mounting plate)

$365.36

P1112640-251

Kit, Platen Roller 203 dpi, ZD621T, ZD621R

$28.68

P1112640-252

Kit, Platen Roller 300 dpi, ZD621T, ZD621R

$28.68

P1080383-234

Attached Power Supply for use with Printer Power Carts. This removes the need for an external Power Supply. Attached Power Supply sits below the printer and is compatible with the Zebra ZD421 and ZD621. Must Purchase AC Power Cable (29928 or 29926) Separately.

$328.44

105950-014

GX430T, KIT, Power Cord, U.S. 120V IEC320C13 (set of 5)

$59.87

T47331IO-EA-6-ADDON

Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core, 6 Rolls. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).

$60.00

T47331IO-EA

Single Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core. Single Roll. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).

$10.00
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