Zebra ZD421
ZD421 (iOS)
ZD421 - iOS Compatible Desktop Barcode Printer (USB, WiFi, Bluetooth) Featuring Zebra’s exclusive Print DNA software suite, the ZD421 is a convenient barcode printer to set up, operate, manage, and maintain – onsite or remotely. Direct thermal, thermal transfer, healthcare, and ribbon cartridge models support a wide variety of applications.- • Max Print Width: 4 Inches
- • Software: Square, Lightspeed
- • Warranty: 2-Year
- • Return Period: 15 Days
- • Lifetime Support
- • Free Shipping
- • Direct Thermal Use: Barcode Label, Jewelry Label
- • Thermal Transfer Use: Barcode Label, Thermal Transfer Ribbon
Elevate your expectations with advanced, compact printers, built for enduring performance
The Zebra ZD421 combines a more powerful architecture with an intuitive five-icon, three-button interface and field-upgradeable connectivity and media handling. It is designed to fit existing workflows today while supporting new applications and security requirements over years of operation.
Choose direct thermal, traditional thermal transfer or the ZD421C ribbon-cartridge configuration. The product family also includes healthcare models, but disinfectant-ready plastics, UV-resistant housing and a medical-grade power supply apply only to those specifically identified configurations.
POSGuys reviews the Zebra ZD421 and the practical reasons to upgrade.
Key Specifications
- Print methods: Direct thermal; thermal transfer by ribbon roll or ZD421C cartridge
- Print width: Up to 4.09 in. at 203 dpi or 4.27 in. at 300 dpi
- Resolution: 203 dpi standard; 300 dpi optional
- Print speed: Up to 6 ips at 203 dpi or 4 ips at 300 dpi
- Memory: 512 MB Flash and 256 MB SDRAM
- Media: Up to 5-in. roll diameter; model-dependent width up to 4.65 in.
- Connectivity: USB 2.0 and USB Host standard; optional Ethernet, serial and dual wireless
- Languages: ZPL II, EPL 2, PDF Direct and Zebra Basic Interpreter 2.0
In the Box
The standard package includes:
- ZD421 printer
- AC power supply
- Region-appropriate power cord
- USB cable
- Quick Start Guide
- Regulatory Guide
Thermal-transfer configurations: 0.5-inch empty ribbon take-up core. Zebra's ZD421 Thermal Transfer package also lists two 300 m non-Zebra ribbon-core adapters and an additional 1-inch core. These ribbon items do not apply universally to direct-thermal or cartridge configurations.
It’s Time to Advance
Powerful Printing with Intuitive Operation
A newer processor lets the ZD421 run more tasks and operations at the same time. Five LED status icons show when media needs replenishment or an issue needs attention, while the three-button interface provides more control than the single-button, single-light design common on basic desktop printers.
Factory- or field-installable communications and media-handling modules allow the printer to evolve after deployment. A cutter or dispenser/peeler can be added without replacing the printer, and wireless or wired network interfaces can be installed as requirements change.
Simple to Setup, Use and Manage Today
Ready to Evolve for Tomorrow
Zebra DNA tools and the Link-OS operating system support integration, daily operation and on-site or remote management. The architecture is designed for future printing and emerging applications, helping organizations preserve familiar workflows while gaining new capabilities.
Change Media Easily
OpenACCESS and color-coded touch points guide operators through media and ribbon changes. The updated media path reduces mess and training time and helps keep the printer available instead of generating avoidable calls to IT.
Multiple Models to Match Your Needs
Flexibility for Nearly Every Use Case
Direct thermal, thermal transfer and healthcare configurations support labels, tags, receipts and wristbands across retail, hospitality, healthcare, government and transportation. The ZD421 is available in 203 dpi and 300 dpi, with media widths that vary between direct thermal, roll-ribbon and cartridge models.
Groundbreaking Cartridge for Instant Ribbon Changes
The ZD421C uses a one-way ribbon cartridge that loads in seconds, removing the need to thread a ribbon roll. A smart chip reports when the ribbon needs replacement; this cartridge capability applies only to the ZD421C, while standard thermal transfer models use 74-meter or 300-meter rolls.
Smart Design for Smarter Operations
Backwards Compatible with Virtually any Existing Printer
ZPL II and EPL 2 support allows established label formats and applications to continue in service. Zebra Printer Emulations can interpret selected languages normally associated with other brands, which simplifies replacement in mixed printer fleets.
Communication to Connect Your Way
USB 2.0 and USB Host are standard. Optional 10/100 Ethernet, RS-232 serial, Wi-Fi 6/Bluetooth 5.3 or Wi-Fi 5/Bluetooth radios support wired and wireless deployments; BLE assists mobile setup, and the Print Touch NFC tag enables tap-to-pair access.
Advanced Flexibility and Features
Moveable Sensor Means More Flexibility
A full-width reflective sensor and multi-position transmissive sensor support gaps, black lines and notches across varied media layouts. The ZD421 handles roll-fed or fan-fold labels and tags, receipt paper and wristbands, with a 5-inch maximum roll diameter.
A Portable Solution to Print Almost Anywhere
The optional 2750 mAh battery supports cordless operation, and a carrying case can bring the printer and battery to the point of application. The carrying case does not fit when a cutter or peeler is attached, a model-specific limitation worth considering when configuring mobile workflows.
Zebra DNA for Printers
Confident and Secure Printing are Yours
Zebra DNA provides applications, utilities and developer tools for setup, integration, operation and ongoing optimization.
Link-OS, Web View, Set-Get-Do commands and Zebra Basic Interpreter 2.0 support integration and printer-side workflows. These tools help the ZD421 remain interoperable and manageable as applications and security policies evolve.
Update, Troubleshoot and Monitor, All from a Single Location
Printer Profile Manager Enterprisediscovers networked printers and distributes configurations through a browser.
Unmatched Printing Security
PrintSecure helps establish secure connections, assess vulnerabilities and block unauthorized access.
Explore Managed Print Services (MPS) with Assurance
Zebra’s Thermal Printers with Zebra DNA Make MPS Easy
With Zebra DNA tools and applications for printers, an MPS provider can remotely manage and optimize the printer, track and automate supplies replenishment and help maintain security.
Markets and Applications
Common uses include shelf, price, pharmacy, information and food-safety labels; receipts, return tags, tickets and event wristbands; specimen, prescription and patient-record labels; document and evidence tracking; and shipping, receiving and packing slips.
Supplies, Services and Support
Zebra Certified Supplies
Zebra pretests labels, tags and ribbons for consistent performance and print quality.
Backed by Zebra’s Worldwide Service and Support
Zebra OneCare Select and Essential plans can add comprehensive coverage, technical support and defined replacement or repair service levels beyond the standard product warranty.
Looking for Compatible Labels or Ribbon?
POSGuys offers labels, standard ribbon, and ribbon cartridges for compatible ZD421 configurations. Having trouble finding the right media? Give our Label Selector Tool a try or contact us for help matching media width, roll and core size, sensing method, ribbon, and printer configuration.
Shop ZD421 Models
ZD4A042-D01X01EZ
Direct Thermal Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB
ZD4A042-D01M00EZ
ZD421 Direct Thermal Barcode Printer; 203 dpi, USB
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB
ZD4A042-D01E00EZ
ZD421 Direct Thermal Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
ZD4A042-D01W01EZ
ZD421 Direct Thermal Barcode Printer; 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB, WiFi, Bluetooth
ZD4A042-301M00EZ
ZD421 Thermal Transfer Barcode Printer; 203 dpi, USB
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB
ZD4A042-301E00EZ
ZD421 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD4A042-301W01EZ
ZD421 Thermal Transfer Barcode Printer; 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD4A042-C01M00EZ
ZD421 Cartridge Barcode Printer; 203 dpi, USB,
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB
ZD4A042-C01E00EZ
ZD421 Cartridge Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB & Ethernet
ZD4A042-C01W01EZ
ZD421 Cartridge Barcode Printer; 203 dpi, USB, 802.11ac
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD4A043-301X01EZ
Thermal Transfer Printer (74/300M) ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A043-C01X01EZ
Thermal Transfer Cartridge Printer ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A043-D01X01EZ
Direct Thermal Printer ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4AH42-D01X01EZ
Direct Thermal Printer ZD421; Healthcare, 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A042-C01X01EZ
Thermal Transfer Cartridge Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A042-301M00GA
Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL,TAA
ZD4A043-D0PE00EZ
Direct Thermal Printer ZD421; 300 dpi, USB, USB Host, Ethernet, BTLE5, APAC Cord bundle (EU, UK, AUS, JP), Swiss Font, EZPL
ZD4AH42-D01E00GA
Direct Thermal Printer ZD421; Healthcare, 203 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
ZD4AH42-301X01EZ
Thermal Transfer Printer (74/300M) ZD421, Healthcare; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A042-301X01EZ
Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
ZD4A042-301X02EZ
Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, ROW, US Cord, Swiss Font, EZPL
ZD4A042-D01E00GA
ZD421 Direct Thermal Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
ZD4A042-301E00GA
ZD421 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD4A042-C01E00GA
ZD421 Cartridge Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB & Ethernet
ZD4A043-D01E00EZ
ZD421 Direct Thermal Barcode Printer; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
ZD4A043-D01M00EZ
ZD421 Direct Thermal Barcode Printer; 300 dpi, USB
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB
ZD4A043-D01W01EZ
ZD421 Direct Thermal Barcode Printer; 300 dpi, USB, WiFi, Bluetooth
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB, WiFi, Bluetooth
ZD4A043-301M00EZ
ZD421 Thermal Transfer Barcode Printer; 300 dpi, USB
DPI:
300
Printer Type:
Thermal Transfer
Interface:
USB
ZD4A043-301E00EZ
ZD421 Thermal Transfer Barcode Printer; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD4A043-301W01EZ
ZD421 Thermal Transfer Barcode Printer; 300 dpi, USB, WiFi
DPI:
300
Printer Type:
Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD4A043-C01M00EZ
ZD421 Cartridge Barcode Printer; 300 dpi, USB
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB
ZD4A043-C01E00EZ
ZD421 Cartridge Barcode Printer; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB & Ethernet
ZD4A043-C01W01EZ
ZD421 Cartridge Barcode Printer; 300 dpi, USB, WiFi, Bluetooth
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD4AH42-D01E00EZ
ZD421 Direct Thermal Barcode Printer; Healthcare, 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Direct Thermal
Extra Features:
Health Care Plastics
Interface:
USB & Ethernet
ZD4AH43-D01E00EZ
ZD421 Direct Thermal Barcode Printer; Healthcare, 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Direct Thermal
Extra Features:
Health Care Plastics
Interface:
USB & Ethernet
ZD4AH42-D01W01EZ
ZD421 Direct Thermal Barcode Printer; Healthcare, 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Printer Type:
Direct Thermal
Extra Features:
Health Care Plastics
Interface:
USB, WiFi, Bluetooth
ZD4AH42-301E00EZ
ZD421 Thermal Transfer Barcode Printer; Healthcare; 203 dpi, USB, Ethernet
DPI:
203
Extra Features:
Health Care Plastics
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD4AH42-301W01EZ
ZD421 Thermal Transfer Barcode Printer; Healthcare; 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Extra Features:
Health Care Plastics
Printer Type:
Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD4AH43-301E00EZ
ZD421 Thermal Transfer Barcode Printer; Healthcare; 300 dpi, USB, Ethernet
DPI:
300
Extra Features:
Health Care Plastics
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD4AH42-C01E00EZ
ZD421 Cartridge Barcode Printer; Healthcare; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Extra Features:
Health Care Plastics
Interface:
USB & Ethernet
ZD4AH42-C01W01EZ
ZD421 Cartridge Barcode Printer; Healthcare; 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Extra Features:
Health Care Plastics
Interface:
USB, WiFi, Bluetooth
ZD4AH43-C01W01EZ
ZD421 Cartridge Barcode Printer; Healthcare; 300 dpi, USB, WiFi, Bluetooth
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Extra Features:
Health Care Plastics
Interface:
USB, WiFi, Bluetooth
ZD4AH43-C01E00EZ
ZD421 Cartridge Barcode Printer; Healthcare; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Extra Features:
Health Care Plastics
Interface:
USB & Ethernet
Outlet Items
ZD4A042-D01M00EZ Direct Thermal Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL CID:4387
Item Number: ZD4A042-D01M00EZ
1 Like New AvailableCID: 4387
ZD4A043-D01W01EZ ZD421 Direct Thermal Barcode Printer; 300 dpi, USB, WiFi, BT4 CID:4607
Item Number: ZD4A043-D01W01EZ
1 Good (like new) open box AvailableCID: 4607
Zebra ZD421
Zebra Printer & Ribbon Bundle (Renewed, Like New). (ZD4A043-C01W01EZ). CID: 4655
Item Number: ZD4A043-C01W01EZ
1 Like New AvailableCID: 4655
Shop ZD421 Accessories
Z1AE-ZD4X1-3C0
OneCare, Essential, Purchased within 30 days of Device, ZD411, ZD421d, ZD421t, ZD421c, 3 Years, Comprehensive
P1112640-015
Ethernet Module, ZD421D, ZD421T, ZD421C, ZD411D, ZD411T, ZD611D, ZD611T
P1112640-030
Upgrade, Cutter, ZD421D, ZD621D - Direct Thermal Models Only
P1112640-230
Upgrade, Cutter - Thermal Transfer model Only
T47331IO-EA
Single Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core. Single Roll. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).
P1079903-026
Replacement Power Supply for Zebra Desktop Printer. 75W/24V with US & EU AC cords. Compatible with: ZD410, ZD411, ZD420, ZD421, ZD620, ZD621, ZD500.
105903-053-3PACK
4" Ribbon Take-Up Core For 4" Thermal Transfer Printers. 0.5" OD. (Three Pack)
T47331IO-EA-6-ADDON
Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core, 6 Rolls. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).
P1112640-017A
Wireless Module, WiFi 802.11ac, MFI 3.0, Bluetooth 4.1, USA & Canada, ZD421, ZD621, ZD411
P1080383-022
Media Core Adaptors for 1.5", 2.0", 3.0" diameter cores. Set of 1 each. Compatible with Zebra ZD421 & ZD621 Printers.
P1080383-234
Attached Power Supply for use with Printer Power Carts. This removes the need for an external Power Supply. Attached Power Supply sits below the printer and is compatible with the Zebra ZD421 and ZD621. Must Purchase AC Power Cable (29928 or 29926) Separately.
29928
Universal AC Power Cord. 8ft (2.4m). 125.0 V / 13 A.
29926
Universal AC Power Cord. 4ft (1.6m). 125.0 V / 13 A.
P1112640-233
Peeler (Dispenser) Upgrade Module for Zebra ZD621T, ZD621R, and ZD421C Printers. NOT backwards compatible with the ZD420 or ZD620
P1080383-603
Battery for Zebra Desktop Printers. Compatible with ZD411, ZD421, ZD621, ZD410, ZD420, and ZD620. Requires Base Housing (P1080383-602 for ZD411/ZD611 / P1080383-600 for ZD421 & ZD621).
P1080383-600
Base Housing for Zebra Printer Battery. Compatible with Zebra ZD421, ZD621, ZD420, and ZD620. Purchase Battery (P1080383-603) Separately.
P1112640-019
Kit, 203 dpi Printhead for Standard Models, ZD421D. Please Note: This product is non-returnable.
P1112640-026
Kit, 203 dpi Printhead for Healthcare Models, ZD421D. Please Note: This product is non-returnable.
P1112640-027
Kit, 300 dpi printhead for Healthcare Models, ZD421D. Please Note: This product is non-returnable.
P1112640-020
Kit, 300 dpi printhead for Standard Models, ZD421D. Please Note: This product is non-returnable.
P1112640-218
Kit, Printhead 203 dpi, ZD421T. Please Note: This product is non-returnable.
P1112640-219
Kit, Printhead 300 dpi, ZD421T. Please Note: This product is non-returnable.
P1112640-031
Kit, Upgrade, Dispenser, ZD421D, ZD621D
Z1AF-ZD4X1-3C0
Zebra OneCare, Essential, Purchased within 30 days of Device, NBD TAT, NA MX only, ZD421d, ZD421t, 3 Years, Comprehensive
P1130666-017A
Kit, Wireless Module, Kit, Wireless Module, WiFi 6, SISO, 802.11ax, MFI 3.0, Bluetooth 5.3, ZD421D, ZD621D, ZD421T, ZD411D, ZD411T, ZD611D, ZD611T, US and Canada
P1134555-239A
Kit, Wireless Module, WiFi6, MIMO, 802.11ax, MFI 3.0, Bluetooth 5.3, USA and Canada, ZD421C, ZD621T, ZD621R
P1130666-239A
Kit, Wireless Module, Kit, Wireless Module, WiFi 6, SISO, 802.11ax, MFI 3.0, Bluetooth 5.3, USA and Canada, ZD421C, ZD621T, ZD621R
P1134555-017A
Kit, Wireless Module, WiFi6, MIMO, 802.11ax, MFI 3.0, Bluetooth 5.3, USA and Canada, ZD421D, ZD621D, ZD421T, ZD411D, ZD411T, ZD611D, ZD611T
P1112640-345
Kit, Upgrade, Partial Cutter, ZD421D, ZD621D
P1116110-009
Kit, Printhead 203dpi, ZD421C
216366
Printer Mount Kit Direct Thermal and Thermal Transfer Models Zebra ZD420 ZD421 ZD620 ZD621
P1116110-010
Kit, Printhead 300dpi, ZD421C
P1116110-025
Kit, Upgrade, Cutter, ZD421C
P1080383-406
Kit, Replacement key for Healthcare printers with a locking media cabinet, Quantity of 5, ZD420D, ZD620D, ZD421D, ZD621D
P1112640-014
Kit, Main Logic Board USB, USB Host, Bluetooth, Modular Connectivity Slot, ZD421D, ZD621D, ZD421T, ZD621T, ZD621R
P1112640-018
Kit, Front Bezel, Standard, ZD421D ZD621D
P1112640-023
Kit, Replacement lock for Healthcare printers with a locking media cabinet, includes 2 keys, ZD421D, ZD621D
P1112640-249
Kit, Shipping Pack, ZD421T, ZD621T, ZD621R
P1112640-054
Kit, Media Core Adaptors for 1.5", 2" & 3" Diameter Media Cores, (set of 2 each), ZD421D, ZD421T
P1112640-231
Kit, Upgrade, Dispenser, ZD421T
P1080383-444
Kit, Buttons for the Latch, 10 Left buttons and 10 Right buttons, ZD420D, ZD620D, ZD421D, ZD621D, ZD220D, ZD230D, ZD888D
P1112640-016
Kit, Serial Module, ZD421D, ZD421T, ZD421C
P1112640-239A
Kit, Wireless Module, WiFi 802.11ac, MFI 3.0, Bluetooth 4.1, USA & Canada, ZD621T, ZD421C