



The Zebra ZD421 brings enterprise manageability to a compact 4-inch desktop printer. Choose direct thermal for ribbon-free output, traditional thermal transfer for 74- or 300-meter ribbons, or a ZD421C cartridge configuration for quick, one-way ribbon changes.
Five status icons, a three-button interface, OpenACCESS and color-coded touchpoints simplify daily use. Zebra DNA, Link-OS and field-installable connectivity and media-handling options help the printer adapt as labeling requirements change.
See the ZD421's controls, media path and configuration choices in this POSGuys product review.
Configuration note: Thermal-transfer roll models include a 0.5-inch empty take-up core, two 300 m non-Zebra ribbon-core adapters and an additional 1-inch take-up core. Media, ribbon and option-specific accessories are sold separately unless the selected option states otherwise.
Roll-ribbon models accept 74-meter ribbon on a 0.5-inch core or 300-meter ribbon on a 1-inch core. ZD421C models use a 74-meter smart cartridge that loads in one direction and reports when ribbon needs replacement. Direct-thermal models require no ribbon.
Movable reflective and transmissive sensors support die-cut, continuous, black-mark, tag, receipt and wristband media. Optional cutter and dispenser/peeler modules fit different finished-label workflows.
Every ZD421 includes USB 2.0, USB Host, Bluetooth Low Energy for mobile setup and an NFC Print Touch tag. Selected configurations add Ethernet, serial, Wi-Fi 5/Bluetooth or Wi-Fi 6/Bluetooth 5.3.
ZPL and EPL support helps preserve established label formats. Zebra DNA, Printer Profile Manager Enterprise and PrintSecure support integration, remote management and security for networked deployments.

Match the selected print method, media width, roll and core size, sensing method and ribbon system to the job. Use the POSGuys Label Selector Tool or contact us for help selecting supplies for a ZD421 configuration.
Direct Thermal Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB
ZD421 Direct Thermal Barcode Printer; 203 dpi, USB
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB
ZD421 Direct Thermal Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
ZD421 Direct Thermal Barcode Printer; 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB, WiFi, Bluetooth
ZD421 Thermal Transfer Barcode Printer; 203 dpi, USB
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB
ZD421 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD421 Cartridge Barcode Printer; 203 dpi, USB,
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB
ZD421 Cartridge Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB & Ethernet
ZD421 Cartridge Barcode Printer; 203 dpi, USB, 802.11ac
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB, WiFi, Bluetooth
Thermal Transfer Printer (74/300M) ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
300
Printer Type:
Thermal Transfer
Interface:
USB
Thermal Transfer Cartridge Printer ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB
Direct Thermal Printer ZD421; 300 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB
Direct Thermal Printer ZD421; Healthcare, 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB
Thermal Transfer Cartridge Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB
Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL,TAA
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB
Direct Thermal Printer ZD421; 300 dpi, USB, USB Host, Ethernet, BTLE5, APAC Cord bundle (EU, UK, AUS, JP), Swiss Font, EZPL
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
Direct Thermal Printer ZD421; Healthcare, 203 dpi, USB, USB Host, Ethernet, BTLE5, US Cord, Swiss Font, EZPL
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
Thermal Transfer Printer (74/300M) ZD421, Healthcare; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB
Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, USA/Canada, US Cord, Swiss Font, EZPL
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB
Thermal Transfer Printer (74/300M) ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, 802.11ax, BT5.3, ROW, US Cord, Swiss Font, EZPL
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB
ZD421 Direct Thermal Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
ZD421 Thermal Transfer Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD421 Cartridge Barcode Printer; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB & Ethernet
ZD421 Direct Thermal Barcode Printer; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
ZD421 Direct Thermal Barcode Printer; 300 dpi, USB
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB
ZD421 Direct Thermal Barcode Printer; 300 dpi, USB, WiFi, Bluetooth
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB, WiFi, Bluetooth
ZD421 Thermal Transfer Barcode Printer; 300 dpi, USB
DPI:
300
Printer Type:
Thermal Transfer
Interface:
USB
ZD421 Thermal Transfer Barcode Printer; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD421 Thermal Transfer Barcode Printer; 300 dpi, USB, WiFi
DPI:
300
Printer Type:
Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD421 Cartridge Barcode Printer; 300 dpi, USB
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB
ZD421 Cartridge Barcode Printer; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB & Ethernet
ZD421 Cartridge Barcode Printer; 300 dpi, USB, WiFi, Bluetooth
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD421 Direct Thermal Barcode Printer; Healthcare, 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
ZD421 Direct Thermal Barcode Printer; Healthcare, 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB & Ethernet
ZD421 Direct Thermal Barcode Printer; Healthcare, 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Printer Type:
Direct Thermal
Interface:
USB, WiFi, Bluetooth
ZD421 Thermal Transfer Barcode Printer; Healthcare; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD421 Thermal Transfer Barcode Printer; Healthcare; 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Printer Type:
Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD421 Thermal Transfer Barcode Printer; Healthcare; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Thermal Transfer
Interface:
USB & Ethernet
ZD421 Cartridge Barcode Printer; Healthcare; 203 dpi, USB, Ethernet
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB & Ethernet
ZD421 Cartridge Barcode Printer; Healthcare; 203 dpi, USB, WiFi, Bluetooth
DPI:
203
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD421 Cartridge Barcode Printer; Healthcare; 300 dpi, USB, WiFi, Bluetooth
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB, WiFi, Bluetooth
ZD421 Cartridge Barcode Printer; Healthcare; 300 dpi, USB, Ethernet
DPI:
300
Printer Type:
Cartridge Roll, Thermal Transfer
Interface:
USB & Ethernet




ZD4A042-D01M00EZ Direct Thermal Printer ZD421; 203 dpi, USB, USB Host, Modular Connectivity Slot, BTLE5, US Cord, Swiss Font, EZPL CID:4387
Item Number: ZD4A042-D01M00EZ
1 Like New AvailableCID: 4387



ZD4A043-D01W01EZ ZD421 Direct Thermal Barcode Printer; 300 dpi, USB, WiFi, BT4 CID:4607
Item Number: ZD4A043-D01W01EZ
1 Good (like new) open box AvailableCID: 4607




Zebra Printer & Ribbon Bundle (Renewed, Like New). (ZD4A043-C01W01EZ). CID: 4655
Item Number: ZD4A043-C01W01EZ
1 Like New AvailableCID: 4655
OneCare, Essential, Purchased within 30 days of Device, ZD411, ZD421d, ZD421t, ZD421c, 3 Years, Comprehensive
Ethernet Module, ZD421D, ZD421T, ZD421C, ZD411D, ZD411T, ZD611D, ZD611T
Upgrade, Cutter, ZD421D, ZD621D - Direct Thermal Models Only
Upgrade, Cutter - Thermal Transfer model Only
Single Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core. Single Roll. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).
Replacement Power Supply for Zebra Desktop Printer. 75W/24V with US & EU AC cords. Compatible with: ZD410, ZD411, ZD420, ZD421, ZD620, ZD621, ZD500.
4" Ribbon Take-Up Core For 4" Thermal Transfer Printers. 0.5" OD. (Three Pack)
Zebra Wax/Resin Ribbon, Black, 4.33" x 243', .5" Core, 6 Rolls. Compatible with all Zebra 4" Desktop Ribbon Printers (This Is a Standard Ribbon, Not Compatible with Cartridge Printers).
Wireless Module, WiFi 802.11ac, MFI 3.0, Bluetooth 4.1, USA & Canada, ZD421, ZD621, ZD411
Media Core Adaptors for 1.5", 2.0", 3.0" diameter cores. Set of 1 each. Compatible with Zebra ZD421 & ZD621 Printers.
Attached Power Supply for use with Printer Power Carts. This removes the need for an external Power Supply. Attached Power Supply sits below the printer and is compatible with the Zebra ZD421 and ZD621. Must Purchase AC Power Cable (29928 or 29926) Separately.
Universal AC Power Cord. 8ft (2.4m). 125.0 V / 13 A.
Universal AC Power Cord. 4ft (1.6m). 125.0 V / 13 A.
Peeler (Dispenser) Upgrade Module for Zebra ZD621T, ZD621R, and ZD421C Printers. NOT backwards compatible with the ZD420 or ZD620
Battery for Zebra Desktop Printers. Compatible with ZD411, ZD421, ZD621, ZD410, ZD420, and ZD620. Requires Base Housing (P1080383-602 for ZD411/ZD611 / P1080383-600 for ZD421 & ZD621).
Base Housing for Zebra Printer Battery. Compatible with Zebra ZD421, ZD621, ZD420, and ZD620. Purchase Battery (P1080383-603) Separately.
Kit, 203 dpi Printhead for Standard Models, ZD421D. Please Note: This product is non-returnable.
Kit, 203 dpi Printhead for Healthcare Models, ZD421D. Please Note: This product is non-returnable.
Kit, 300 dpi printhead for Healthcare Models, ZD421D. Please Note: This product is non-returnable.
Kit, 300 dpi printhead for Standard Models, ZD421D. Please Note: This product is non-returnable.
Kit, Printhead 203 dpi, ZD421T. Please Note: This product is non-returnable.
Kit, Printhead 300 dpi, ZD421T. Please Note: This product is non-returnable.
Kit, Upgrade, Dispenser, ZD421D, ZD621D
Zebra OneCare, Essential, Purchased within 30 days of Device, NBD TAT, NA MX only, ZD421d, ZD421t, 3 Years, Comprehensive
Kit, Wireless Module, Kit, Wireless Module, WiFi 6, SISO, 802.11ax, MFI 3.0, Bluetooth 5.3, ZD421D, ZD621D, ZD421T, ZD411D, ZD411T, ZD611D, ZD611T, US and Canada
Kit, Wireless Module, WiFi6, MIMO, 802.11ax, MFI 3.0, Bluetooth 5.3, USA and Canada, ZD421C, ZD621T, ZD621R
Kit, Wireless Module, Kit, Wireless Module, WiFi 6, SISO, 802.11ax, MFI 3.0, Bluetooth 5.3, USA and Canada, ZD421C, ZD621T, ZD621R
Kit, Wireless Module, WiFi6, MIMO, 802.11ax, MFI 3.0, Bluetooth 5.3, USA and Canada, ZD421D, ZD621D, ZD421T, ZD411D, ZD411T, ZD611D, ZD611T
Kit, Upgrade, Partial Cutter, ZD421D, ZD621D
Kit, Printhead 203dpi, ZD421C
Printer Mount Kit Direct Thermal and Thermal Transfer Models Zebra ZD420 ZD421 ZD620 ZD621
Kit, Printhead 300dpi, ZD421C
Kit, Upgrade, Cutter, ZD421C
Kit, Replacement key for Healthcare printers with a locking media cabinet, Quantity of 5, ZD420D, ZD620D, ZD421D, ZD621D
Kit, Main Logic Board USB, USB Host, Bluetooth, Modular Connectivity Slot, ZD421D, ZD621D, ZD421T, ZD621T, ZD621R
Kit, Front Bezel, Standard, ZD421D ZD621D
Kit, Replacement lock for Healthcare printers with a locking media cabinet, includes 2 keys, ZD421D, ZD621D
Kit, Shipping Pack, ZD421T, ZD621T, ZD621R
Kit, Media Core Adaptors for 1.5", 2" & 3" Diameter Media Cores, (set of 2 each), ZD421D, ZD421T
Kit, Upgrade, Dispenser, ZD421T
Kit, Buttons for the Latch, 10 Left buttons and 10 Right buttons, ZD420D, ZD620D, ZD421D, ZD621D, ZD220D, ZD230D, ZD888D
Kit, Serial Module, ZD421D, ZD421T, ZD421C
Kit, Wireless Module, WiFi 802.11ac, MFI 3.0, Bluetooth 4.1, USA & Canada, ZD621T, ZD421C